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MOA MOA MOA EfficacyEfficacyPALOMA-2 Study designPatient Characteristics Primary endpoint Secondary end point PALOMA-3Study design Patient Characteristics Primary endpoint Secondary end point SurvivalFinal analysis Subgroup analysis Prespecified groups Updated Subgroup analysis Safety Safety PALOMA pooled analysis Adverse reactions  & Laboratory abnormalities PALOMA 2 Adverse Events PALOMA 3 Adverse Events IBRANCE consistent  safety profile Pooled analysis of patients aged ≥65 years in the PALOMA trials No evidence of cumulative or delayed toxicity with up to 50 months Patients with visceral diseases GI ,  Liver toxicities, and QTC Dosing Dosing Once daily dosing Dose Modification Real-World EvidenceReal-world EvidenceIBRANCE is the only CDK4/6 inhibitor with >5 years of real-world experience Real-world data provide additional information Favorable progression free rates IRIS Study In the real world, IBRANCE benefits GuidelinesGuidelinesNCCN Guidelines ESMO Guidelines

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Information on how to access Ibrance® (palbociclib) prescribing information and adverse event reporting can be found at the bottom of the page.

Improved tumour response in first-line treatment with IBRANCE + letrozole versus placebo + letrozole (secondary end point)1
Adapted from Finn RS, et al. 2016.1
Data cut-off date: 26 February 2016.
*Defined as confirmed complete response or partial response.1
†Defined as confirmed CR, PR or SD for ≥24 weeks.1

CR= complete response; CBR= clinical benefit rate; ITT= intention-to-treat; LET= letrozole; ORR= objective response rate; PLA= placebo; PR= partial response; SD= stable disease.
References:Finn RS, et al. N Engl J Med. 2016;375(20):1925-1936.Turner NC, et al. Ann Oncol. 2018;29(3):669-680.

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