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Information on how to access Ibrance® (palbociclib) prescribing information and adverse event reporting can be found at the bottom of the page.
IBRANCE + letrozole/fulvestrant is recommended by international guidelines as a treatment option for HR+/HER2- mBC1,2
AI= aromatase inhibitor; CDK = cyclin-dependent kinase; FUL= - Fulvestrant; HER2- = human epidermal growth factor receptor 2-negative; HR+ = hormone receptor-positive; LHRH = luteinising hormone-releasing hormone;
mBC = metastatic breast cancer; NCCN = National Comprehensive Cancer Network.

References: 1. National Comprehensive Cancer Network. Clinical practice guidelines in Oncology. Breast Cancer Version 6.2024 — November 11, 2024. NCCN Website. https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf Accessed November 2024. 2. Cardoso F, et al. Ann Oncol. 2018;29(8):1634-1657.
IBRANCE + letrozole/fulvestrant is recommended by international guidelines as a treatment option for HR+/HER2- mBC1,2
ABC4 = Fourth International Advanced Breast Cancer Consensus Conference; AI= aromatase inhibitor; CDK = cyclin-dependent kinase; ESO = European School of Oncology; ESMO = European Society for Medical Oncology; ET = endocrine therapy; FUL= - Fulvestrant; HER2- = human epidermal growth factor receptor 2-negative; HR+ = hormone receptor-positive; LHRH = luteinising hormone-releasing
hormone; mBC = metastatic breast cancer.

References: 1. National Comprehensive Cancer Network. Clinical practice guidelines in Oncology. Breast Cancer Version 6.2024 — November 11, 2024. NCCN Website. https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf Accessed November 2024. 2. Cardoso F, et al. Ann Oncol. 2018;29(8):1634-1657.

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